Summary of “Improved Peyronie’s Disease Curvature Outcomes Using a Novel Collagenase Administration Protocol” Collagenase Clostridium Histolyticum (CCH) can be used on men with Peyronie’s Disease (PD) to improve penile curvature. Since the release of CCH in 2014 studies have consistently shown penile curvature improvements in men with PD in the 14-23˚ range (similar to findings […]
The following is a summary of an article recently published in the Journal of Sexual Medicine. We provide these summaries in the hopes that they will help patients keep up to date on the latest research published on the topics of PD and male infertility. This particular study’s goal was to define the factors that
What is Peyronie’s disease? Peyronie’s disease (PD) is a connective tissue disorder affecting the tunica albuginea and is characterized by penile curvature resulting from fibrosis and plaque deposits. PD can not only cause physical pain, but it can also cause psychological and psychosexual issues. PD affects between 0.4 to 20+% of the male population (depending
What Causes Peyronie’s Disease? Read More »
Peyronie’s Disease (PD) is a fibrotic disorder of the tunica albuginea of the corpora cavernosa and is progressive in nature. Consequently, this disorder is linked to a decrease in sexual performance and self-confidence. Currently, treatments include oral medication, surgical reconstruction, and injectable therapy. The purpose of this study was to compare the costs of treatment
Peyronie’s Disease (PD) is a connective tissue disorder of the penis affecting the tunica albuginea. This disorder can lead to penile deformity and local pain. No one knows what causes PD; however, it is thought that PD could be caused by repetitive microvascular trauma, causing inflammation, excessive collagen deposition, and fibrinogenesis on the tunica albuginea.
***Trost Commentary and Key Take-Home Points*** The current manuscript is a review article (summarizes research publications performed by other teams) which discusses the role of penile prosthetics in men with Peyronie’s Disease. Penile prosthetics have a clear role for the treatment of PD men who have erectile dysfunction which does not respond to PDE5 inhibitors (i.e. Viagra, Levitra,
***Trost Commentary and Key Take-Home Points*** This is a great commentary which highlights the significant need that we have for better medications to treat Peyronie’s Disease. For decades, dozens of medicines, herbals, topicals, and energy types of treatments have been used to try to treat Peyronie’s Disease. And, with few exceptions, none of them have showed any true promise in
***Trost Commentary and Key Take-Home Points*** The current study evaluates the use of intralesional hyaluronic acid to treat Peyronie’s Disease. This is one of 4 different types of injections which are most commonly reported, with the others being collagenase (Xiaflex), interferon, and verapamil. This specific injection is more commonly used in Europe, particularly now that collagenase is no
***Trost Commentary and Key Take-Home Points*** This study was one that we conducted soon after RestoreX became available. Our goal was to determine if the device resulted in any benefits or not in treating Peyronie’s Disease. My experience with traction devices to that point had not been very good. Specifically, we had previously performed a study where we evaluated whether
Peyronie’s Disease can be a diagnosis that can be troubling for men to even accept or speak to their physician about but it is important to know the causes of this condition.
Causes and diagnosis of Peyronie’s Disease Read More »