Summary of “Improved Peyronie’s Disease Curvature Outcomes Using a Novel Collagenase Administration Protocol” Collagenase Clostridium Histolyticum (CCH) can be used on men with Peyronie’s Disease (PD) to improve penile curvature. Since the release of CCH in 2014 studies have consistently shown penile curvature improvements in men with PD in the 14-23˚ range (similar to findings […]
The following is a summary of an article recently published in the Journal of Sexual Medicine. We provide these summaries in the hopes that they will help patients keep up to date on the latest research published on the topics of PD and male infertility. This particular study’s goal was to define the factors that
Peyronie’s Disease (PD) is a fibrotic disorder of the tunica albuginea of the corpora cavernosa and is progressive in nature. Consequently, this disorder is linked to a decrease in sexual performance and self-confidence. Currently, treatments include oral medication, surgical reconstruction, and injectable therapy. The purpose of this study was to compare the costs of treatment
***Trost Commentary and Key Take-Home Points*** The current study evaluates the use of intralesional hyaluronic acid to treat Peyronie’s Disease. This is one of 4 different types of injections which are most commonly reported, with the others being collagenase (Xiaflex), interferon, and verapamil. This specific injection is more commonly used in Europe, particularly now that collagenase is no
***Trost Commentary and Key Take-Home Points*** This manuscript represents a nice review of outcomes of patients who undergo surgery post Xiaflex treatment. The key finding from the study is that surgery remains a viable option for men who do not experience a sufficient improvement with Xiaflex. I think it’s important to recognize that the key finding from the study should
—Dr. Trost Commentary and Key Take Home Points— This current study evaluates the use of two different injection treatments for men with early phase Peyronie’s Disease. This study was performed by an experienced group of researchers in Italy. This is important to recognize though, as the gold-standard injection treatment (Xiaflex) is more difficult to use
—Dr. Trost Commentary and Key Take-home Points— The current manuscript evaluates the efficacy of Xiaflex in improving curvature in men with less common deformities, including those with downward curvatures, hourglass deformity, or decreased penile length. Not surprisingly, results showed that the therapy is indeed able to improve curvature in these conditions as well. In our own experience, we