Treatments

Summary of “Modern treatment strategies for penile prosthetics in Peyronie’s disease: a contemporary clinical review”

***Trost Commentary and Key Take-Home Points*** The current manuscript is a review article (summarizes research publications performed by other teams) which discusses the role of penile prosthetics in men with Peyronie’s Disease.  Penile prosthetics have a clear role for the treatment of PD men who have erectile dysfunction which does not respond to PDE5 inhibitors (i.e. Viagra, Levitra, …

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Summary of “What role do pharmaceuticals play in the treatment of Peyronie’s disease and is there a need for new emerging drugs?”

***Trost Commentary and Key Take-Home Points*** This is a great commentary which highlights the significant need that we have for better medications to treat Peyronie’s Disease.  For decades, dozens of medicines, herbals, topicals, and energy types of treatments have been used to try to treat Peyronie’s Disease.  And, with few exceptions, none of them have showed any true promise in …

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Summary of “Intralesional Injection of Hyaluronic Acid in Patients Affected With Peyronie’s Disease: Preliminary Results From a Prospective, Multicenter, Pilot Study”

***Trost Commentary and Key Take-Home Points*** The current study evaluates the use of intralesional hyaluronic acid to treat Peyronie’s Disease.  This is one of 4 different types of injections which are most commonly reported, with the others being collagenase (Xiaflex), interferon, and verapamil.  This specific injection is more commonly used in Europe, particularly now that collagenase is no …

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Summary of “OUTCOMES OF A NOVEL PENILE TRACTION DEVICE (RESTOREX) IN MEN WITH PEYRONIE’S DISEASE: A RANDOMIZED, SINGLE-BLINDED, CONTROLLED TRIAL”

***Trost Commentary and Key Take-Home Points*** This study was one that we conducted soon after RestoreX became available.  Our goal was to determine if the device resulted in any benefits or not in treating Peyronie’s Disease.  My experience with traction devices to that point had not been very good.  Specifically, we had previously performed a study where we evaluated whether …

Summary of “OUTCOMES OF A NOVEL PENILE TRACTION DEVICE (RESTOREX) IN MEN WITH PEYRONIE’S DISEASE: A RANDOMIZED, SINGLE-BLINDED, CONTROLLED TRIAL” Read More »

Summary of “Penile Size Restoration With Nondegloving Approach for Peyronie’s Disease: Initial Experience”

***Trost Commentary and Key Take-Home Points*** The current manuscript examines a modification to a technique that is performed at the time of penile prosthesis placement to achieve greater penile length.  Basically, several years back, a technique was developed known as the ‘sliding’ technique, where the penis was basically nearly amputated, stretched, and placed over a …

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Summary of “Pathophysiology and Future Therapeutic Perspectives for Resolving Fibrosis in Peyronie’s Disease”

***Trost Commentary and Key Take-Home Points*** The current review article discusses some of the complexities of the process by which Peyronie’s Disease leads to penile fibrosis and scarring. The key take home point is that, to date, there are no good treatments which have been shown to prevent the progression of Peyronie’s Disease scarring. Although …

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Summary of “Shockwave Therapy in the Treatment of Peyronie’s Disease”

***Trost Commentary and Key Take-Home Points*** Shockwave therapy is a very hot topic in sexual medicine and is very commonly advertised for Peyronie’s Disease and erectile dysfunction.  However, as of August, 2020, shockwave therapy is not ready for primetime and should not be recommended or used in Peyronie’s Disease.  Although a full description of data behind that comment is …

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Summary of “Peyronie’s Disease Intervention Studies: An Exploration of Modern-Era Challenges in Study Design and Evaluating Treatment Outcomes”

***Trost Commentary and Key Take-Home Points*** This was a summary that Matt, Larry, Giorgio and I worked on to help other physicians better understand the Peyronie’s scientific literature. There are many challenges that come with trying to interpret Peyronie’s studies, and because of this, it is often important to critically evaluate any paper that is …

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Summary of “Characteristics of Men With Peyronie’s Disease and Collagenase Clostridium Histolyticum Treatment Failure: Predictors of Surgical Intervention and Outcomes”

***Trost Commentary and Key Take-Home Points*** This manuscript represents a nice review of outcomes of patients who undergo surgery post Xiaflex treatment.  The key finding from the study is that surgery remains a viable option for men who do not experience a sufficient improvement with Xiaflex.  I think it’s important to recognize that the key finding from the study should …

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Summary of “Contemporary Thoughts on the Role of Shockwave Therapy in Peyronie’s Disease”

–Trost Commentary and Key Take-Aways– Shock wave therapy has recently become in vogue as an alternative treatment option for PD.  However, patients need to recognize that there really are no consistent data demonstrating any benefits.  The American Urological Association and the Sexual Medicine Society of North America both have position statements that indicate that shock …

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Summary of "How Atypical Penile Curvature Influence Clinical Outcomes in Patients with Peyronie’s Disease Receiving Collagenase Clostridium Histolyticum Therapy?"

—Dr. Trost Commentary and Key Take-home Points—  The current manuscript evaluates the efficacy of Xiaflex in improving curvature in men with less common deformities, including those with downward curvatures, hourglass deformity, or decreased penile length.  Not surprisingly, results showed that the therapy is indeed able to improve curvature in these conditions as well.  In our own experience, we …

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