Summary of “Improved Peyronie’s Disease Curvature Outcomes Using a Novel Collagenase Administration Protocol” Collagenase Clostridium Histolyticum (CCH) can be used on men with Peyronie’s Disease (PD) to improve penile curvature. Since the release of CCH in 2014 studies have consistently shown penile curvature improvements in men with PD in the 14-23˚ range (similar to findings […]
Peyronie’s Disease (PD) is a fibrotic disorder of the tunica albuginea of the corpora cavernosa and is progressive in nature. Consequently, this disorder is linked to a decrease in sexual performance and self-confidence. Currently, treatments include oral medication, surgical reconstruction, and injectable therapy. The purpose of this study was to compare the costs of treatment
Peyronie’s Disease (PD) is a connective tissue disorder of the penis affecting the tunica albuginea. This disorder can lead to penile deformity and local pain. No one knows what causes PD; however, it is thought that PD could be caused by repetitive microvascular trauma, causing inflammation, excessive collagen deposition, and fibrinogenesis on the tunica albuginea.
***Trost Commentary and Key Take-Home Points*** The current manuscript is a review article (summarizes research publications performed by other teams) which discusses the role of penile prosthetics in men with Peyronie’s Disease. Penile prosthetics have a clear role for the treatment of PD men who have erectile dysfunction which does not respond to PDE5 inhibitors (i.e. Viagra, Levitra,
***Trost Commentary and Key Take-Home Points*** This is a great commentary which highlights the significant need that we have for better medications to treat Peyronie’s Disease. For decades, dozens of medicines, herbals, topicals, and energy types of treatments have been used to try to treat Peyronie’s Disease. And, with few exceptions, none of them have showed any true promise in
***Trost Commentary and Key Take-Home Points*** The current study evaluates the use of intralesional hyaluronic acid to treat Peyronie’s Disease. This is one of 4 different types of injections which are most commonly reported, with the others being collagenase (Xiaflex), interferon, and verapamil. This specific injection is more commonly used in Europe, particularly now that collagenase is no
***Trost Commentary and Key Take-Home Points*** This study was one that we conducted soon after RestoreX became available. Our goal was to determine if the device resulted in any benefits or not in treating Peyronie’s Disease. My experience with traction devices to that point had not been very good. Specifically, we had previously performed a study where we evaluated whether
***Trost Commentary and Key Take-Home Points*** The current manuscript examines a modification to a technique that is performed at the time of penile prosthesis placement to achieve greater penile length. Basically, several years back, a technique was developed known as the ‘sliding’ technique, where the penis was basically nearly amputated, stretched, and placed over a
***Trost Commentary and Key Take-Home Points*** The current review article discusses some of the complexities of the process by which Peyronie’s Disease leads to penile fibrosis and scarring. The key take home point is that, to date, there are no good treatments which have been shown to prevent the progression of Peyronie’s Disease scarring. Although
***Trost Commentary and Key Take-Home Points*** Shockwave therapy is a very hot topic in sexual medicine and is very commonly advertised for Peyronie’s Disease and erectile dysfunction. However, as of August, 2020, shockwave therapy is not ready for primetime and should not be recommended or used in Peyronie’s Disease. Although a full description of data behind that comment is
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